Testimonial
"The quality of the ingredients and the forms of the nutrients used in this complex are one of a kind! I personally use this for histamine issues around my monthly cycle and have clients who are using it as part of a gut health and skin protocol with great results!"
Abby
Histamine Metabolism
The best way to think about histamine is the bucket analogy. If your histamine bucket overflows, this can result in chronic inflammation. The aim of this complex is to improve the emptying of the bucket by supporting the enzymes that metabolise histamine whilst also inhibiting the release. We use a variety of ingredients for this.
Creatine Monohydrate - Enhancing Histamine Metabolism and Energy Production
Creatine monohydrate indirectly promotes histamine metabolism by supporting the activity of histamine-metabolizing enzymes, such as diamine oxidase (DAO) and histamine-N-methyltransferase (HNMT). By facilitating the breakdown of histamine, creatine reduces its accumulation and helps alleviate histamine intolerance symptoms. Additionally, creatine plays a vital role in cellular energy production, ensuring optimal function and efficiency in histamine metabolism.
Organic Acerola: Natural Vitamin C - Antioxidant Defense and Histamine Modulation
Acerola is a rich source of natural vitamin C which is a potent antioxidant. Vitamin C protects against histamine-induced oxidative stress, which can exacerbate histamine intolerance symptoms. By neutralizing free radicals and reducing oxidative damage, vitamin C helps maintain a balanced histamine response. Furthermore, vitamin C contributes to the normal function of the immune system
L-Theanine - Calming Inflammation and Modulating Histamine Release
L-theanine, derived from green tea, exerts anti-inflammatory effects by inhibiting the activation of pro-inflammatory signaling molecules, such as nuclear factor-kappa B (NF-κB). By reducing inflammation, L-theanine helps modulate histamine release and mitigate histamine-related discomfort. Moreover, L-theanine promotes relaxation by enhancing alpha brain wave activity, which can reduce stress-induced histamine release.
Bromelain - Digestive Support and Histamine Breakdown
Bromelain, a proteolytic enzyme found in pineapple, aids in the digestion of proteins, including histamine-rich foods. By facilitating protein breakdown, bromelain supports proper digestion and minimizes the absorption of intact histamine molecules. This digestive support helps reduce histamine accumulation in the body and alleviates digestive symptoms associated with histamine intolerance. Bromelain has also been shown to inhibit the production of pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). By reducing inflammation, bromelain may indirectly decrease the release or synthesis of histamine in certain immune cells.
Boswellia - Anti-inflammatory Action and Histamine Balance
Boswellia possesses potent anti-inflammatory properties due to its active components, such as boswellic acids. By inhibiting the activity of pro-inflammatory enzymes, including 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2), boswellia helps reduce histamine-induced inflammation and promotes a balanced histamine response.
Copper - The Central Atom of Histamine Metabolism Enzymes
Minerals play an important role in histamine balance and copper is no exception. Copper is an essential cofactor for DAO, the primary enzyme responsible for breaking down histamine in the gut. Adequate copper levels ensure proper DAO activity, facilitating efficient histamine metabolism and preventing its accumulation.
Vitamin B6 - Enzyme Co-Factor in Histamine Clearance
Vitamin B6, also known as pyridoxine or P5P, plays a crucial role in the metabolism of histamine. It is a cofactor in the production of enzymes that metabolise histamine, further supporting its regulation. While vitamin B6 may not directly lower histamine levels, its role in histamine metabolism suggests that it can help alleviate the effects of histamine-related conditions.
Bifidobacterium infantis and Bifidobacterium longum - Gut Microbiota Support for Improved Histamine Tolerance
Bifidobacterium infantis and Bifidobacterium longum, two beneficial probiotic strains, play a crucial role in supporting a healthy gut microbiota. By promoting a balanced microbial environment, these strains help optimize digestion and reduce histamine production in the gut. Furthermore these two specific strains have been to suppress allergic type symptoms and decrease histamine levels.
Our Histamine Metabolism Support Complex
✔ 90 capsules per jar or refill
✔ 45 Day supply (2 capsules per day)
✔ Suitable for vegetarians and vegans
✔ Independently tested
✔ Zero additives, binders or flow agents
✔ Pullulan capsule (derived from tapioca)
✔ Manufactured in a GMP-certified facility to ensure the highest quality & purity
Label Note: Our recent batch of labels shows 1ug of copper per serving (2 capsules), however this is meant to say 1mg (as per the nutrition info on this page) which is the correct value corresponding to the % of RDA. This correction will be fixed on the next label run.
Research
Beyond Muscles: The Untapped Potential of Creatine
Acerola, an untapped functional superfruit: a review on latest frontiers
Theanine is a candidate amino acid for pharmacological stabilization of mast cells
Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells
Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb
Inhibition of mast cell histamine release by copper
Effect of pyridoxine on histamine liberation and degranulation of rat mast cells
If it's your first time purchasing this product we would recommend selecting the jar and then utilising the refill pouches for top ups as these can be delivered through the letterbox. Please note that a maximum of two refill pouches can fit inside a large letter (royal mail) if you wish to have your order delivered through the letterbox.
If it's your first time purchasing this product we would recommend selecting the jar and then utilising the refill pouches for top ups as these can be delivered through the letterbox. Please note that a maximum of two refill pouches can fit inside a large letter (royal mail) if you wish to have your order delivered through the letterbox.
The capsule size is 0. Capsule sizes are named by numerical values, numbered: 000, 00, 0, 1, 2, 3, 4 and 5 from biggest to smallest.
The capsule size is 0. Capsule sizes are named by numerical values, numbered: 000, 00, 0, 1, 2, 3, 4 and 5 from biggest to smallest.
This supplement is not suitable for those pregnant. Please consult with your healthcare provider if you are breastfeeding.
This supplement is not suitable for those pregnant. Please consult with your healthcare provider if you are breastfeeding.
As with any new supplement, always start with 1 capsule after food first and slowly build up from there or as professionally directed. It is preferable to take the complex after or during breakfast to help reduce histamine build up throughout the day.
As with any new supplement, always start with 1 capsule after food first and slowly build up from there or as professionally directed. It is preferable to take the complex after or during breakfast to help reduce histamine build up throughout the day.
This complex uses a combination of natural compounds that work syngeristically to improve the metabolism of histamine and reduce its effects. Drugs on the other hand target very specific receptors in the body so it is difficult to compare the two. We do not know whether this supplement is as effective as anti histamine drugs but overtime we may be able to assess this.
This complex uses a combination of natural compounds that work syngeristically to improve the metabolism of histamine and reduce its effects. Drugs on the other hand target very specific receptors in the body so it is difficult to compare the two. We do not know whether this supplement is as effective as anti histamine drugs but overtime we may be able to assess this.
Anti-histamine drugs can induce drowsiness by working against histamine which is one of our 'awake' based hormones/neurotransmitters. Our formula is much more gentle than anti-histamine drugs and does not tend to cause drowsiness but this may vary from person to person.
Anti-histamine drugs can induce drowsiness by working against histamine which is one of our 'awake' based hormones/neurotransmitters. Our formula is much more gentle than anti-histamine drugs and does not tend to cause drowsiness but this may vary from person to person.
We recommend taking no more than 2 capsules in one serving, and a maximum of 4 per day or as professionally directed.
We recommend taking no more than 2 capsules in one serving, and a maximum of 4 per day or as professionally directed.
We recommend taking our histamine metabolism support complex after food initially after which you may explore taking it away from food.
We recommend taking our histamine metabolism support complex after food initially after which you may explore taking it away from food.
If you are pregnant, nursing, taking any medications or have any medical condition, we always advise you consult your doctor or healthcare professional before use.
If you are pregnant, nursing, taking any medications or have any medical condition, we always advise you consult your doctor or healthcare professional before use.