We've recently launched our mitochondrial support supplement which contains a compound known as Pyrroloquinoline quinone, otherwise known as PQQ. In this post we wanted to dive into what this compound is and its functions.
PQQ is a small molecule that is found in plants, bacteria, and some animal tissues. It has a chemical structure similar to that of vitamins and is classified as a redox cofactor, which means that it can participate in chemical reactions that involve the transfer of electrons. PQQ has gained attention in recent years due to its potential health benefits, including its ability to act as an antioxidant and support cognitive function. Recent evidence suggests that compounds like PQQ are components of interstellar dust, considered precursors to organic life.
One of the primary functions of PQQ is its ability to act as an antioxidant. Antioxidants are substances that can neutralize harmful molecules called free radicals, which can cause damage to cells and contribute to the development of diseases such as cancer and heart disease. PQQ has been shown to be a potent antioxidant, with the ability to scavenge free radicals and prevent their damaging effects. It has also been shown to stimulate the production of other antioxidants in the body, including superoxide dismutase (SOD) and glutathione.
PQQ has also been shown to modulate the expression of certain genes that are involved in energy metabolism and mitochondrial function. In particular, PQQ has been shown to increase the expression of genes that are involved in the production of mitochondria and the transport of proteins into mitochondria, which may help to improve their function.
PQQ has also been studied for its potential cognitive benefits. Some research has suggested that PQQ may support cognitive function by protecting neurons, or brain cells, from oxidative stress. It has also been shown to promote the growth and survival of neurons, which may help to improve brain function.
In addition to its potential cognitive benefits, PQQ has also been studied for its effects on energy metabolism and mitochondrial function.
Mitochondria are the powerhouses of cells, responsible for producing the energy from oxidative phosphorylation that cells need to function. PQQ has been shown to improve the function of mitochondria and increase the production of energy in cells. This may have a variety of potential health benefits, including improving physical performance and reducing fatigue.
There is also some evidence to suggest that PQQ may have anti-inflammatory effects. Inflammation is a normal response to injury or infection, but chronic inflammation has been linked to a number of diseases, including heart disease, diabetes, and cancer. PQQ has been shown to reduce inflammation in animal studies, and there is some evidence to suggest that it may have similar effects in humans.
PQQ is found naturally in small amounts in a variety of foods, including kiwifruit and peppers. Although the body can produce small amounts of PQQ, more may be needed in times of oxidative stress. In this situation additional PQQ may be able to help balance redox status so that we can make energy efficiently.
The available evidence suggests that PQQ may have a variety of potential benefits for human health, including its ability to act as an antioxidant, support cognitive function, improve energy metabolism and mitochondrial function, and reduce inflammation. As with any supplement, it is important to speak with a healthcare provider before starting to use PQQ, especially if you have any existing health conditions or are taking any medications.
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